Is At-Home Ketamine Therapy Safe? What the Research Says

Dr. Sam Zand
May 20
2 min read

As ketamine therapy continues gaining popularity for treating depression, PTSD, anxiety, and other mental health conditions, more people are turning to the convenience of at-home options. But a common—and important—question remains: Is at-home ketamine therapy safe?

Let’s look at what the research says, what safety measures are in place, and how Anywhere Clinic makes at-home ketamine treatment both effective and secure.

Anywhere Clinic provides mental health services such as medication management, ketamine therapy, and adolescent/family psychotherapy

What the Research Says About Ketamine Safety

Ketamine was originally developed as an anesthetic in the 1960s and has been used safely in hospitals for decades. More recently, studies have shown that sub-anesthetic doses of ketamine—especially in the form of lozenges or nasal sprays—can provide rapid relief for treatment-resistant depression, suicidal ideation, PTSD, OCD, and more.

According to a 2021 review published in The American Journal of Psychiatry, ketamine has shown strong efficacy and safety profiles when administered in controlled, monitored settings. Clinical trials continue to support its short-term safety, especially when protocols include supervision, screening, and integration support.

At-home ketamine therapy follows a similar model—just from the comfort of your home. Reputable programs like Anywhere Clinic include detailed screenings, physician oversight, and ongoing check-ins to make sure patients are safe and supported.

Common Mental Health Conditions Treated With Ketamine

At Anywhere Clinic, we use at-home ketamine therapy to support individuals managing:

Treatment-resistant depression
PTSD and trauma-related disorders
Anxiety and panic disorders
Suicidal thoughts
OCD
Bipolar depression

Each person’s treatment plan is tailored to their needs and progress is carefully monitored by our licensed psychiatric providers.

Built-In Safety Features of At-Home Ketamine Treatment

At-home doesn’t mean unsupervised. Here’s how we keep you safe:

Comprehensive screening: We assess your physical and mental health history before treatment is approved.
Virtual check-ins: You’ll meet with a licensed provider to prepare for treatment and discuss what to expect.
Clear safety guidelines: We provide step-by-step instructions—like no driving, no alcohol, and having a trusted person nearby during your session.
Professional follow-up: We schedule post-session check-ins to assess how you're feeling and adjust your care plan if needed.

Is At-Home Ketamine Right for You?

At-home ketamine therapy isn’t for everyone. It’s best for patients who:

Have already tried other treatments with limited success
Don’t have a history of substance misuse
Can create a calm, safe environment at home
Are willing to follow medical guidance closely

Our team will help you determine if you’re a good fit and ensure you feel fully prepared.

Insurance and Payment Options

At Anywhere Clinic, we currently accept self-pay for ketamine therapy. This allows us to offer highly personalized care with flexible scheduling. Payment plans may be available—just reach out to learn more about pricing and session packages.